The two recent studies have emphasized the potential effects of SARS-COV-2 infection during pregnancy.These studies have found that placenta abnormalities are related to fetal bleeding from new crown infections during pregnancy.Researchers are now monitoring children who are in contact with the virus before the birth to investigate whether there is a long -term neurological impact.
Prior to the emergence of SARS-COV-2 in 2020, a large number of studies have already studied the effects of virus infection during pregnancy.Due to the immunosuppressive nature of pregnancy, people know that virus infection may be dangerous, and it will increase the risk of maternal incidence, death or premature birth.
However, even for pregnant women, a mild infection will have a long -term development impact on the fetus in their growth.For example, the infamous Zika virus often does not have any symptoms or just mild diseases in adults, but infection during pregnancy may lead to children’s birth defects and nervous system diseases.
Influenza infections during pregnancy have also been fully studied.Some long -term studies reviewed children born during the influenza in 1918, and showed that contact with influenza in the uterus would lead to various harmful effects after adulthood, from the increase in cardiovascular disease to the decrease in education.
Recently, modern research associates the mother’s influenza infection with the high incidence rate of autism and schizophrenia.However, how the child’s neuroscular development is affected by the exposure of pregnancy virus exposure.Some studies have shown that fever during pregnancy is a key factor in destroying fetal nerve development, especially in the first three months of pregnancy.Other studies have pointed out that inflammatory members have triggered changes in fetal brain growth.
The important thing is that the long -term impact on neurological development was discovered after mild virus infections during pregnancy.These infections generally do not cause major medical intervention, nor will it affect birth weight or length of pregnancy.
Therefore, considering this pre-existing evidence, researchers have been closely studying the impact of COVID-19 during pregnancy.Until now, three years after such a new type of coronary virus appeared, we began to understand how the prenatal infection affects the development of the fetus.
A new study led by researchers at the University of London University studied samples of more than 600 fetal brain tissue. These samples were collected from selective termination of pregnancy from 2020 to 2022.
About 5%of the analysis samples were found to have leather bleeding. In all these samples, the researchers also detected the existence of SARS-COV-2.Katie Long, the chief investigator of the study, said it was unusual to find so many hemorrhagic brain tissue samples in a random collection.
Long said: "Although the brain occasionally bleeds occasionally, so many situations have occurred in 21 months. Now the most important thing is that we are exposed to children before childbirth to COVID-19 children.Tracking so that we can determine whether there are any long -lasting neural development effects. "
Researchers are most concerned about observing that most of the detected bleeding was found in the fetal brain tissue in the late first and early stages of the first pregnancy.Researchers have pointed out that it is unclear whether these abnormalities will be solved naturally during healthy pregnancy, but in this critical early stage of neurossent development, the immune activation of the mother may cause long -term problems.
The researchers wrote: "… Most [detected bleeding] is between 12 and 14pcw. This is a key window for human fetal brain development. At this time. It is necessary to further investigate to understand whether the effects of these cortex tissues are long -term or can be solved with minimal consequences. Immune cell reactions may have positive results, resulting in some of these bleeding solutions.There are many long -lasting effects in nervous development. "
Another newly published research team from Austria used MRI to study the effects of SARS-COV-2 infection on the placenta and fetus.This is the first prenatal MRI study to study the placenta structure of pregnant women and the work of fetal organs recovered from the COVID-19 infection.
The study conducted a MRI survey of 38 pregnant women who confirmed the infection of SARS-COV-2.These scans were performed on average about 80 days after each participant’s first PCR test was positive.Each positive participant matches a non -infected control group with similar fetal age.
The results show that compared with the control group, those participants infected with SARS-COV-2 showed significantly more placental abnormalities.These include changes in the shape and thickness of the placenta and vascular lesions.
The study also shows that the PRE-OMicron variant of the virus causes greater placenta damage than the currently circulating OMICRON variant.Researchers pointed out that this difference may be because the disease caused by Omitron is not so serious compared to previous variants, but it may also be the impact of the increase in the virus.
The researchers wrote: "Different placental lesions caused by different virus variants may be due to the low pathogenicity of Omitron variants, and the vaccination coverage rate is high with the progress of great popularity.-COV-2-OMicron’s two pregnant women who did not vaccinate vaccine appeared spherical placenta, but only one of the women who vaccinated the Sanlian vaccine appeared. "
Of course, these two studies are restricted by the same precautions faced by many such surveys.They cannot determine the cause and effect, nor can they explain the long -term impact of any referenced abnormal phenomenon.
It takes many years to understand the potential connection between the researchers in the uterine SARS-COV-2 exposure and neurological disorders.A study published in mid-2022 provided some initial clues and studied hundreds of 12-month-old children. The mothers of these children faced the COVID-19 infection during the first wave of abortion.
The results of these studies show that compared with the influential control group, the proportion of developmental disorders related to motion function or speech and language is higher.However, because many of these babies are natives, it is unclear whether the virus infection directly leads to neuros development problems, or whether the COVID-19 is just a premature birth, and the premature birth itself is related to the slow development.
Other researchers said in the research in 2022 that it was too early to diagnose children’s developmental obstacles.Dorothy Bishop, the development of neurosteners of Oxford University, put forward special criticism of the study, and believes that it is not credible to be effectively diagnosed by children when they are 12 months old.
Dixon said: "As an expert in children’s language barriers, it is difficult for me to see how these situations were diagnosed in such small children, because even if a child does not produce any languages at all, this will not be abnormal.Obviously, pregnant women should try their best to avoid infection with COVID-19, but if they really have this disease, their babies will not have obvious neurosteural problems in the first year after birth. "
Lucilla Poston, the material and fetal health researcher at King London, said that the infection of COVID-19 during pregnancy may of course affect the development of the fetal brain.Although further research in the next few years will inevitably provide insights on this association, Poston said that it is obvious that vaccination of COVID-19 vaccines during pregnancy will be the key to reducing infection.
"We know that severe virus infections may affect the fetus’s brain, but this important study shows the first time that this situation may occur in pregnant women infected by COVID," Poston said when commenting on the fetus of the King’s College."No matter what the reason is, the direct impact of the virus or the indirect consequence of the mother infection. This study emphasizes the necessity of vaccination of the COVID-19 vaccine for pregnant women, thereby avoiding the complications of mothers and babies."
The King of London is conducting a study called BIBS (Study on Brain Imaging).It will track children born with a positive mothers who are positive for COVID during pregnancy.Using MRI imaging and behavioral assessment, researchers will observe the brain development before the age of 4.
Fetal tissue research was published in the "Brain" magazine, and the placental MRI research was published in the "Health of the Willow Dao area".