Do hepatitis B virus take antiviral drugs with pregnant women?

HBV-DNA can pass the virus to the fetus in intrauterine infection through the placenta during pregnancy.You may have heard that in the third trimester of pregnancy to prevent the mother’s infection by injection of hepatitis B immunoglobulin.However, after a large number of clinical studies, this method cannot effectively prevent the occurrence of HBV’s intrauterine infection.

The high level of pregnant women’s serum HBV-DNA is the most important risk factor that leads to the spread of maternal and infant transmission. Some research has proved that the newborn of HBV-DNA ≤ 10^6 IU / ML.Maternal and baby transmission occurred.

After infant receiving hepatitis B vaccine and hepatitis B immunoglobulin, the risk of maternal and infant transmission is positively related to the mother’s HBV-DNA virus level.In recent years, a large number of studies have shown that when mothers at pregnancy HBV-DNA levels> 2×10^5 IU / ml, nucleoside antiviral drugs in the middle and late pregnancy reduce the level of virus levels, thereby greatly reducing the risk of infection in the palace. Newborn childrenAfter birth, hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) were adopted.

my country’s "Hepatitis B Viruses Maternal and Baby Communication Prevention of Maternal and Child Communication (2020)" Recommended suggestions: HBV-DNA> 2 × 10^5 IU/ML, starting with antiviral drugs at 28-32 weeks of pregnancy, the first choice for Naojo of Nuren Wee ester, closely observe the ending of pregnancy and childbirth, and stop the drug on the day of childbirth.Pregnant women HBEAG are positive but if there is no condition to detect HBV-DNA, they can also take antiviral drugs in accordance with this solution.

Therefore, not all pregnant women carried by hepatitis B virus need antiviral treatment, and the level of virus during pregnancy also fluctuates. Whether you need to take medicines need to be evaluated by a doctor and decide.

After giving birth, you need to follow up every 2-3 months.


Production Science Group of the Chinese Medical Association’s Obstetrics and Gynecology Branch, Medical Branch of the Chinese Medical Association. The hepatitis B virus virus maternal and baby communication prevention clinical guidelines (2020). Chinese gynecological magazine, 2020,55 (5): 291-299.

This article is reproduced from Youan Angel Online, author: Tian Ruihua.

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