Ballad: Hepatitis B pregnant women should be used to block hepatitis B immunoglobulin to block it?Listen to the doctor what to say

Some women have known that they are hepatitis B virus infection before pregnancy, and they also know that hepatitis B may be infected with hepatitis B through maternal and infant transmission. He also knows that children need to inject hepatitis B vaccine after birth.

But what they know is often that: I do not know that the liver function and hepatitis B virus nucleic acid (HBV DNA) need to be tested regularly during pregnancy to understand the risk of the maternal and baby transmission of hepatitis B virus.Hepatitis B immunoglobulin.

They will hear some methods to prevent the spread of hepatitis B mother and baby from people older than her.

For example, many people think that hepatitis B mothers cannot breastfeed; others think that in the late pregnancy, a few needles can block the mother and infant transmission of hepatitis B virus, and so on.

The needle they said is called hepatitis B immunoglobulin.

It is considered that the hepatitis B immunoglobulin is injected in the late pregnancy, and the mother and baby transmission of hepatitis B virus can be blocked. Such a wrong understanding has a long history and has a certain harm.

The reason why such a wrong understanding is mainly because in the past, such clinical trials have been done. Some pregnant women have injected hepatitis B immunoglobulin, and the manufacturer’s propaganda has misunderstood the role of hepatitis B immunoglobulin.

The results of such clinical trials did not find that hepatitis B mothers used hepatitis B immunoglobulin during pregnancy, which had special value to blocking mother and baby.

Therefore, there is no precise basis for evidence -based medicine in pregnancy.

Hepatitis B Immunoglobulin (HBIG), also known as hepatitis B high -efficiency immunoglobulin, is concentrated and purified from healthy human plasma from hepatitis B antibody. The invasion of hepatitis B virus has a passive immune effect.

The essence of hepatitis B immunoglobulin is the hepatitis B surface antibody (HBSAB), which is a protein (globulin).

The hepatitis B immunoglobulin, which is currently used, is a screened healthy blood donor. After injection of hepatitis B vaccine and generating high -level HBSAB, it is prepared to use blood.Most of the immunoglobulin is 100U.

Because hepatitis B immunoglobulin needs to be extracted from the blood of the human body, there are fewer sources, and the production requires a lot of bacteria and virus levels, and the cost is relatively high.

The half -life of hepatitis B immunoglobulin is about 3 to 4 weeks in the body.The half -life refers to the effective ingredients of this preparation, which is metabolized and consumed in the body in the body.

Therefore, hepatitis B immunoglobulin can only be used as temporary protection measures for high -risk groups, and cannot replace hepatitis B vaccine and is widely used for prevention.It cannot be used for treatment, because for those with hepatitis B virus infection, the amount of hepatitis B immunoglobulin is injected into the human body, the antibody level can be described as a glass of water, and it does not have much to reduce the viral amount.

Hepatitis B immunoglobulin is a passive immune preparation, which provides temporary immune protection capabilities for susceptible people, and is not an antibody produced by itself.It is mainly used for the prevention of a newborns born of a highly contagious HBSAG carrier (especially the Da Sanyang), or the prevention of the people exposed by hepatitis B virus (HBV).

Usage of hepatitis B immunoglobulin

When a newborn for mother HBEAG positive and HBV DNA -positive, it is best to injected 100 IU in the newborn muscle within 12 hours of birth.

The current guidelines recommend that only need to be injected once, and the second needle is not meaningful.

At the same time, hepatitis B vaccine is injected in accordance with the regulations (injection of the first needle and hepatitis B immunoglobulin in different limbs) to block maternal and infant transmission during the perinatal period.

In the past, it has been reported that pregnant women who are positive and HBV DNA -positive for HBEAG have been injected once a month in the next three months of pregnancy.

However, evidence -based medical analysis has no affirmation of this method.

In addition, in recent years, after strong oral nucleoside (acid) analog antiviral treatment and conventional vaccination, it can effectively reduce the transmission of hepatitis B maternal and baby, and the success rate of the regular practice block is almost close to 100%.

In 2005, 2010, and 2015, the "Guidelines for Prevention and Control of Chronic Hepatitis B" and the hepatitis B guidelines in various countries in recent years have not been recommended to apply hepatitis B immunoglobulin in the later stages of pregnancy.

Hepatitis B immunoglobulin is also used for high -risk groups of HBV infection, such as hemodialysis, liver transposter, hemodiacat patients, and those who are stabbed by HBV -contaminated appliances, etc., all have certain prevention effects.

For those who are infected with hepatitis B virus, if you do n’t know if you have antibodies or the level of antibody is not high, hepatitis B immunoglobulin should be injected immediately, which must not exceed 48 hours later.

Finally, remind those who are pregnant with hepatitis B virus infected with women who injeped hepatitis B immunoglobulin during pregnancy to prevent the baby from infection with hepatitis B. Although it may be safe for meRisk: One is some of the disadvantages of blood products itself, and the other is that this wrong understanding may miss the truly useful blocking measures.

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